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No. 01 of 07

What 5X to 80X means, fold ratio versus standardised content

A salvia "10X" is a fold ratio of leaf to product. How that differs from a stated salvinorin A content, and why two extracts with the same X can differ.

Updated

On a salvia extract, the X is a fold ratio: it states how many grams of dried leaf one gram of product stands for. A 20X is labelled as one gram carrying the salvinorin A of twenty grams of leaf. The US Drug Enforcement Administration lists "extract-enhanced leaves of various strengths (e.g., 5X, 10X, 20X, 30X)" among the salvia products on sale (DEA, December 2025).

A fold ratio says nothing about milligrams by itself. It is a recipe ratio, and its result depends on the leaf it started from.

The physical product

A salvia extract in the X series is dried leaf material with a raised salvinorin A content. It is not a liquid and not the pure compound. Avalon describes its extracts this way too: "concentrated leaf material", and on the 30X page, "not a liquid". Liquid products exist separately as tinctures and sprays, which carry a different kind of ratio; see extract, leaves, tincture or spray.

Two ways to declare a herbal product

Regulated herbal products in the European Union are declared in one of three ways, set out by the European Medicines Agency (EMA guideline on declaration of herbal substances and preparations, 2010). Salvia extracts are not regulated products, but the categories are a useful yardstick:

TypeWhat is declaredSalvia equivalent
StandardisedA fixed content of a named compound, within a tolerance"36 mg salvinorin A per gram"
QuantifiedA content range of a named compound"between 30 and 40 mg per gram"
OtherOnly the ratio of plant to product (the drug extract ratio, written as 10:1)"10X"

A plain X label belongs in the third group. It tells you the ratio, and a product declared that way is, in the EMA's words, "essentially defined by [its] production process". A content figure moves a product towards the first group, because it names the compound and an amount.

Why the same X can mean different amounts

Salvia leaf is not uniform. Across published analyses, dried leaf has measured anywhere from 0.89 to 7.8 mg of salvinorin A per gram (Chambers et al., 2022, review of earlier studies). In the same study, a raw leaf product bought online measured 1.54 mg per gram. Three leaf products sold in Japan measured 3.2 to 5.0 mg per gram (Tsujikawa et al., 2008).

Run a tenfold ratio across that range and the arithmetic gives very different products:

Starting leafA true 10X would holdA true 40X would hold
1.5 mg/g15 mg/g60 mg/g
3.6 mg/g36 mg/g144 mg/g
5.0 mg/g50 mg/g200 mg/g

This is arithmetic, not a measurement: it shows how much room a fold label leaves. The middle row matches the figures Avalon states for its own 10X and 40X.

A second source of difference is that nobody checks X labels. The lab tests page shows what independent analyses found, including a 20X that measured lower than a 10X from the same seller.

How Avalon labels its extracts

Avalon gives a fold ratio and a stated content for each extract. Its figures follow a straight line of 3.6 mg per X:

StrengthStated salvinorin A per gramPack sizeStated amount per pack
5X18 mg1 g18 mg
10X36 mg1 g36 mg
15X54 mg1 g54 mg
20X72 mg1 g72 mg
30X108 mg0.5 g54 mg
40X144 mg0.5 g72 mg
80X288 mg0.5 g144 mg

The shop describes its extracts as "standardized". The figures are the shop's own; no published study has tested Avalon products. The last column is simple multiplication and is useful when you compare packs: half a gram of 30X carries the same stated amount as one gram of 15X.

What a buyer can take from a label

  • Two numbers beat one. A label with both an X and a milligram figure tells you the intended ratio and the intended content. A label with only an X tells you the ratio.
  • Compare within one seller. The X steps of one seller are at least meant to relate to each other. Between sellers, the same X can hide a several-fold difference.
  • Per pack, not only per gram. Pack sizes differ between strengths, so the stated amount per pack is the fairer comparison.
  • The number is not a quality grade. A higher X is a smaller amount for the same effect, not a better product.

The calm, step-by-step route through these strengths is on the choosing page. For how small the amounts are in practice, the lab tests page has the background.